Blowfish Cipher, despite its efficiency and speed, has inherent design vulnerabilities. Its 64-bit block size can lead to issues with large data transfers due to the birthday problem, increasing collision chances. Additionally, Blowfish’s key schedule is slow, making it unsuitable for applications requiring frequent key changes. The cipher also lacks a proof of security, leaving its strength largely dependent on the absence of successful cryptanalysis. Lastly, weak keys in Blowfish can lead to bad S-boxes, causing potential security risks.