In gRPC, versioning can be handled in several ways. One approach is to use package versioning where different versions of the service are kept in separate packages or namespaces. This allows clients to choose which version to use. Another method is using new methods for new versions. If a change doesn’t break compatibility, add a new method with the changes. For breaking changes, create a new service definition alongside the old one. The old and new services can coexist on the same API endpoint, allowing clients to gradually migrate from the old to the new service.