Yes, you can do it by using a function autoSysFields() in your server-side scripting. Whenever you are updating a record set the autoSysFields() to false.
example:
var gr = new GlideRecord(‘incident’);
gr.query();
if(gr.next()){
gr.autoSysFields(false);
short_description = “Test from Examsmyntra” ;
gr.update();
}